top of page

Selected Publications

VDAC in membrane mimetics - biophysical analyses

Ferens, F.G., Summers, W.A., Bharaj, A., Stetefeld, J., Court, D.A. (2021) A C-terminally truncated variant of Neurospora crassa VDAC assembles into a partially functional form in the mitochondrial outer membrane and forms multimers in vitro. Front. Physiol. 12:1441.

Ferens, F.G., Patel, T.R., Oriss, G., Court, D.A., Stetefeld, J. A (2019) A cholesterol analog induces an oligomeric reorganization of VDAC. Biophys J. 116:847-859. (image)

 

Transporters in mitochondrial inner membranes

 

Islam, M.D., Harrison, B.D., Li, J.-Y., Court, D.A. (2023) Do mitochondria use efflux pumps to protect their ribosomes from antibiotics? Microbiology 169:001272.

 

 

 

 

 

 

 

Optimizing phage production

 

Wiebe, K.G., Cook, B.W.M, Lightly, T.J., Court, D.A., Theriault, S.S. (2024) Investigation into scalable and efficient enterotoxigenic Escherichia coli bacteriophage production. Scientific Reports 14, Article number: 3618 (source of image)

 

 

 

 

 

 

 

 

Life in the absence of VDAC, or in the presence of VDAC variants

Shuvo, S.R., Motnenko, A., Krohkin, O.V., Spicer, V., *Court, D.A. (2022) Proteomic shifts reflecting oxidative stress and reduced capacity for protein synthesis, and alterations to mitochondrial membranes in Neurospora crassa lacking VDAC. Microorganisms. 10, 198 (image)

Shuvo, S.R., Wiens, L.M., Subramaniam, S., Treberg, J.R., Court D.A. (2019) Increased reactive oxygen species production and maintenance of membrane potential in VDAC-less Neurospora crassa mitochondria. J. Bioenerg. Biomembr. 51:341-354. (image)

Shuvo, S.R., Kovaltchouk, U., Zubaer, A., Kumar, A., Summers, W.A.T., Donald, L.J., Hausner, G., Court, D.A. (2017) Functional characterization of an N-terminally-truncated mitochondrial porin expressed in Neurospora crassa. Can. J. Microbiol. 63:730-738.

Ferens, F.G., Spicer, V., Krokhin O., Motnenko, A., Summers, W.A.T., Court, D.A. (2017) A deletion variant partially complements a porin-less strain of Neurospora crassa. Bioch. Cell Biol. 95:318-327.

VDAC hexamer only Fraser.png

                      Model of VDAC hexamer in                  

              decylmaltoside/ergosterol micelles             

Potential mechanisms of drug efflux from mitochondria

SRS 2022 image.png

Proteomic changes in the absence of VDAC/porin

Shuvo etc for web.png

       ETC changes in the absence of VDAC/porin    

bottom of page